Eriksson KF & Lindgarde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. diabetology 34891-898 (1991).
Rejeski, WJ et al. Lifestyle change and mobility in obese adults with type 2 diabetes. N. Engl. J. Med. 3661209-1217 (2012).
Stampfer, MJ, Hu, FB, Manson, JE, Rimm, EB & Willett, WC Primary prevention of coronary heart disease in women through diet and lifestyle. N. Engl. J. Med. 34316-22 (2000).
Helmrich SP, Ragland DR, Leung RW & Paffenbarger RS Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 325147-152 (1991).
Rawshani, A. et al. Risk factors, mortality, and cardiovascular outcomes in patients with type 2 diabetes. N. Engl. J. Med. 379633–644 (2018).
Sanford, JA et al. Molecular Transducers of Physical Activity Consortium (MoTrPAC): mapping the dynamic responses to exercise. Cell 1811464–1474 (2020).
Contrepois, K. et al. Molecular choreography of acute exercise. Cell 1811112–1130.e16 (2020).
Morville T, Sahl RE, Moritz T, Helge JW & Clemmensen C. Plasma metabolome profiling of resistance exercise and endurance exercise in humans. Cell Rep. 33108554 (2020).
Lewis, GD et al. Metabolic signatures of exercise in human plasma. science translation medication 233ra37 (2010).
Roberts, LD et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 1996-108 (2014).
Stanford, KI et al. 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab. 271111–1120.e3 (2018).
Reddy, A. et al. pH-gated succinate secretion regulates muscle remodeling in response to exercise. Cell 18362–75.e17 (2020).
Yuan, Y. et al. Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J 39e103304 (2020).
Klein, AB et al. Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise. nat. community 121041 (2021).
Green, HJ & Fraser, IG Differential effects of exercise intensity on serum uric acid concentration. Med.Sci. sports exercise 2055-59 (1988).
Schranner, D., Kastenmüller, G., Schönfelder, M., Römisch-Margl, W. & Wackerhage, H. Metabolite concentration changes in humans after a bout of exercise: a systematic review of exercise metabolomics studies. Sports. Medical Open 611 (2020).
Gaffney, B. & Cunningham, EP Estimation of genetic trend in racing performance of thoroughbred horses. Nature 332722-724 (1988).
Hagenfeldt, L. & Naglo, AS New conjugated urinary metabolites in intermediate type maple syrup urine disease. clinical chim. Acta 16977-83 (1987).
Bottesini C, Tedeschi T, Dossena A & Sforza S. Enzymatic production and degradation of cheese-derived non-proteolytic aminoacyl derivatives. Amino Acids 46441–447 (2014).
Sgarbi, E. et al. Microbial origin of non-proteolytic aminoacyl derivatives in long ripened cheeses. Food Microbiol. 35116-120 (2013).
Jansen, RS et al. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. proc. Natl Acad. science United States 1126601-6606 (2015).
Sharma, R. et al. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. J.Clin. invest 131e136055 (2021).
The Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562367–372 (2018).
Locke, AE et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518197-206 (2015).
Ringholm, S. et al. PGC-1α is required for exercise and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS ONE 8the64123 (2013).
Kim, YJ, Kim, HJ, Lee, WJ & Seong, JK A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model. Lab. anime reserve 361–8 (2020).
DeWolf, CJF et al. cGMP transport by vesicles from human and mouse erythrocytes. FEBS J 274439-450 (2007).
Smith, CA et al. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. chem. 78779-787 (2006).
Agudelo, LZ et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 15933-45 (2014).
Coxon, JP et al. GABA concentration in sensorimotor cortex following high-intensity exercise and relationship to lactate levels. J Physiol. 596691–702 (2018).
Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation (FAO, WHO, UNU, 2005).
Sanjana NE, Shalem O & Zhang F. Improved vectors and genome-wide libraries for CRISPR screening. nat. methods 11783–784 (2014).
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